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Droxinostat

CAT: 0013-GTR19169888-05Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169888-05Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Droxinostat is a selective histone deacetylase (HDAC) inhibitor, primarily targeting HDAC6 and HDAC8 with IC50 values of 2.47 μM and 1.46 μM, respectively. It demonstrates over 8-fold selectivity against HDAC3 and shows no activity against several other HDAC isoforms. This compound is a valuable research tool for studying epigenetic mechanisms in both cellular and animal models of cancer and neurological diseases.
CAS Number
99873-43-5
Product Name Alternative
Droxinostat, cancer, Apoptosis, NS41080, NS-41080, NS 41080, inhibit, Inhibitor, hepatocellular carcinoma (HCC), HDAC9, HDAC8, HDAC3, HDAC6, HDAC, HDAC10, histone deacetylase (HDAC), Histone deacetylases
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology
Purity
99.76% (May vary between batches)
Solubility
DMSO:46 mg/mL (188.76 mM) ; Ethanol:46 mg/mL (188.76 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.21 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
Cc1cc (Cl) ccc1OCCCC (=O) NO
Molecular Formula
C11H14ClNO3
Molecular Weight
243.69
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide

4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide is an aromatic ether.

CAS Number99873-43-5
PubChem CID568416
IUPAC Name4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide
Molecular FormulaC11H14ClNO3
Molecular Weight243.68
XLogP2.8
Topological Polar Surface Area58.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Heavy Atom Count16
Formal Charge0
Complexity225
SMILES
CC1=C(C=CC(=C1)Cl)OCCCC(=O)NO
InChI
InChI=1S/C11H14ClNO3/c1-8-7-9(12)4-5-10(8)16-6-2-3-11(14)13-15/h4-5,7,15H,2-3,6H2,1H3,(H,13,14)
InChIKey
JHSXDAWGLCZYSM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide
CAS: 99873-43-5
CID: 568416
Formula: C11H14ClNO3
MW: 243.68
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight243.68
XLogP32.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass243.0662210
Monoisotopic Mass243.0662210
Topological Polar Surface Area58.6 Ų
Heavy Atom Count16
Formal Charge0
Complexity225
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-13267-01Droxinostat

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