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Droxinostat

CAT: 0804-HY-13267-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13267-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Droxinostat (NS 41080) is a histone deacetylase (HDAC) inhibitor. Droxinostat selectively inhibits HDAC3, HDAC6, and HDAC8 with IC50 values of 16.9 μM, 2.47 μM, and 1.46 μM, respectively. Droxinostat can be used for the research of hepatocellular carcinoma (HCC) [1][2].
CAS Number
99873-43-5
Product Name Alternative
NS 41080
UNSPSC
12352005
Hazard Statement
H302, H315, H318, H335
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Droxinostat.html
Concentration
10mM
Purity
98.91
Solubility
DMSO : ≥ 150 mg/mL
Smiles
ClC1=CC=C(C(C)=C1)OCCCC(NO)=O
Molecular Formula
C11H14ClNO3
Molecular Weight
243.69
Precautions
H302, H315, H318, H335
References & Citations
[1]Liu J, et al. Droxinostat, a Histone Deacetylase Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cell Lines via Activation of the Mitochondrial Pathway and Downregulation of FLIP. Transl Oncol. 2016 Feb;9 (1) :70-8.|[2]Wood TE et al. Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther. 2010 Jan;9 (1) :246-56.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC3; HDAC6; HDAC8

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CatalogName
A4100-10Droxinostat

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