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GW-5074

CAT: 0013-GTR19169845-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169845-01Size:5 mg
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Description
GW 5074 is a potent and selective c-Raf inhibitor (IC50=9 nM) with demonstrated utility in studying MAPK/ERK signaling pathways in cellular and animal models of cancer and neurological diseases. It exhibits high specificity, showing no activity against a panel of other kinases including JNK, MEK, and VEGFR2.
CAS Number
220904-83-6
Product Name Alternative
C-Raf, Apoptosis, inhibit, Inhibitor, GW5074, GW-5074, GW 5074, Raf, Raf kinases, Raf1 Kinase Inhibitor I
Field of Research
Neuroscience
Purity
>98%
Bioactivity
C-Raf1 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 50 mg/ml) .
Smiles
C (=C1C=2C (NC1=O) =CC=C (I) C2) C3=CC (Br) =C (O) C (Br) =C3
Molecular Formula
C15H8Br2INO2
Molecular Weight
521.0
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
3- (3,5-Dibromo-4-hydroxybenzylidene) -5-iodo-1,3-dihydroindol-2-one

Chemical Information

GW-5074

GW5074 is a potent and selective c-Raf inhibitor.

CAS Number220904-83-6
PubChem CID5924208
IUPAC Name(3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one
Molecular FormulaC15H8Br2INO2
Molecular Weight520.94
XLogP4.6
Topological Polar Surface Area49.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count21
Formal Charge0
Complexity447
SMILES
C1=CC2=C(C=C1I)/C(=C/C3=CC(=C(C(=C3)Br)O)Br)/C(=O)N2
InChI
InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
InChIKey
LMXYVLFTZRPNRV-KMKOMSMNSA-N
Chemical Structure
2D Structure
2D structure of GW-5074
CAS: 220904-83-6
CID: 5924208
Formula: C15H8Br2INO2
MW: 520.94
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight520.94
XLogP34.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass520.79460
Monoisotopic Mass518.79665
Topological Polar Surface Area49.3 Ų
Heavy Atom Count21
Formal Charge0
Complexity447
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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