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Indoximod

CAT: 0013-GTR19169828-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169828-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Indoximod (NLG-8189) is a methylated tryptophan analog that acts as an immune checkpoint inhibitor by targeting indoleamine 2,3-dioxygenase (IDO) . Its inhibition of IDO prevents tryptophan depletion, thereby countering T-cell anergy and immunosuppression. This small molecule is utilized in both in vitro and in vivo research to study cancer immunotherapy, autoimmune diseases, and T-cell function.
CAS Number
110117-83-4
Product Name Alternative
Tryptophan, Trp mimetic, Inhibitor, IDO, NLG 8189, NLG8189, NLG-8189, mTORC1, Indoleamine 2,3-Dioxygenase, Indoleamine 2,3Dioxygenase (IDO), Indoleamine 2,3-Dioxygenase (IDO), Indoleamine2,3Dioxygenase, Indoleamine2,3Dioxygenase (IDO), Indoximod, Indoximod (NLG-8189), immunotherapeutic vaccines, inhibit, cancer, 1-Methyl-D-tryptophan
Field of Research
Immunology & Inflammation
Purity
>98%
Bioactivity
IDO modulator / tryptophan mimetic
Form
Powder
Solubility
Soluble in DMSO (greater than 25 mg/ml) .
Smiles
Cn1cc (C[C@@H] (N) C (O) =O) c2ccccc12
Molecular Formula
C12H14N2O2
Molecular Weight
218.25
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
1-Methyl-D-tryptophan

Chemical Information

Indoximod

Indoximod is an indolyl carboxylic acid.

CAS Number110117-83-4
PubChem CID405012
IUPAC Name(2R)-2-amino-3-(1-methylindol-3-yl)propanoic acid
Molecular FormulaC12H14N2O2
Molecular Weight218.25
XLogP-1.3
Topological Polar Surface Area68.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count16
Formal Charge0
Complexity270
SMILES
CN1C=C(C2=CC=CC=C21)C[C@H](C(=O)O)N
InChI
InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m1/s1
InChIKey
ZADWXFSZEAPBJS-SNVBAGLBSA-N
Chemical Structure
2D Structure
2D structure of Indoximod
CAS: 110117-83-4
CID: 405012
Formula: C12H14N2O2
MW: 218.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight218.25
XLogP3-1.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass218.105527694
Monoisotopic Mass218.105527694
Topological Polar Surface Area68.3 Ų
Heavy Atom Count16
Formal Charge0
Complexity270
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
C12922-200mgIndoximod
C6586-200(S)-Indoximod
T60266(Rac) -Indoximod
A4747-100(Rac)-Indoximod
HY-N0707-01(S) -Indoximod
HY-16724R-01Indoximod (Standard)
A14397-500Indoximod 500mg
A14397-100Indoximod 100mg
B4900-200Indoximod (NLG-8189)

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