EMD638683

CAT: 0013-GTR19169741-07Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19169741-07Size:50 mg

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Description

EMD638683 is a potent and selective serum- and glucocorticoid-regulated kinase (SGK) inhibitor with an IC50 of 3 μM. This small molecule is a valuable research tool for investigating SGK1's role in hypertension, renal function, and cellular ion transport in both in vitro and in vivo models.

CAS Number

1181770-72-8

Product Name Alternative

Inhibitor, EMD638683, EMD-638683, EMD 638683, inhibit, SGK1, SGK, Serum and glucocorticoid-regulated kinase, Serum-glucocorticoid regulated kinase

Field of Research

Metabolism Research

Purity

95.47% (May vary between batches)

Solubility

DMSO:50 mg/mL (137.23 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.49 mM)

Smiles

CCc1c (C) c (O) ccc1C (=O) NNC (=O) C (O) c1cc (F) cc (F) c1

Molecular Formula

C18H18F2N2O4

Molecular Weight

364.34

References & Citations

Sheyda Bahiraii er al. Role of Inositol Hexakisphosphate Kinases in Vascular Smooth Muscle Cell Calcification International Journal of Molecular Sciences, (2026)

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Emd638683

inhibits serum- and glucocorticoid-inducible kinase 1 (SGK1); structure in first source

CAS Number	1181770-72-8
PubChem CID	44182398
IUPAC Name	N'-[2-(3,5-difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide
Molecular Formula	C18H18F2N2O4
Molecular Weight	364.3
XLogP	2.8
Topological Polar Surface Area	98.7
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Heavy Atom Count	26
Formal Charge	0
Complexity	498

SMILES

CCC1=C(C=CC(=C1C)O)C(=O)NNC(=O)C(C2=CC(=CC(=C2)F)F)O

InChI

InChI=1S/C18H18F2N2O4/c1-3-13-9(2)15(23)5-4-14(13)17(25)21-22-18(26)16(24)10-6-11(19)8-12(20)7-10/h4-8,16,23-24H,3H2,1-2H3,(H,21,25)(H,22,26)

InChIKey

SSNAPUUWBPZGOY-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1181770-72-8

CID: 44182398

Formula: C18H18F2N2O4

MW: 364.3

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	364.3
XLogP3	2.8
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	364.12346338
Monoisotopic Mass	364.12346338
Topological Polar Surface Area	98.7 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	498
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
BUP02999-01	EMD638683
A15079-100	EMD638683 100mg
A15079-25	EMD638683 25mg
HY-15193R-01	EMD638683 (Standard)
A15079-50	EMD638683 50mg
A15079-5	EMD638683 5mg
A15079-10	EMD638683 10mg
A15079-1	EMD638683 1mg
MBS386751-01	EMD638683 S-Form
T11181-01	EMD638683 R-Form

EMD638683

Chemical Information

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