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EMD638683 (Standard)

CAT: 0804-HY-15193R-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15193R-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EMD638683 (Standard) is the analytical standard of EMD638683. This product is intended for research and analytical applications. EMD638683 is a highly selective SGK1 inhibitor, with an IC50 value of 3 μM.
CAS Number
1181770-72-8
UNSPSC
12352100
Target
Reference Standards; SGK
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Metabolic Disease; Cancer
Smiles
CC1=C(CC)C(C(NNC(C(O)C2=CC(F)=CC(F)=C2)=O)=O)=CC=C1O
Molecular Formula
C18H18F2N2O4
Molecular Weight
364.34
References & Citations
[1]Ackermann TF, et al. EMD638683, a novel SGK inhibitor with antihypertensive potency. Cell Physiol Biochem. 2011;28 (1) :137-46.|[2]Towhid ST, et al. Inhibition of colonic tumor growth by the selective SGK inhibitor EMD638683. Cell Physiol Biochem. 2013;32 (4) :838-48.|[3]Xi X, et al. Serum-glucocorticoid regulated kinase 1 regulates macrophage recruitment and activation contributing to monocrotaline-induced pulmonary arterial hypertension. Cardiovasc Toxicol. 2014 Dec;14 (4) :368-78.|[4]Zhou H, et al. Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failure. FASEB J. 2015 Sep;29 (9) :3737-49.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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