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Refametinib

CAT: 0013-GTR19169740-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169740-05Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Refametinib (RDEA119) is a potent and selective, ATP-noncompetitive inhibitor of MEK1 and MEK2 kinases, exhibiting IC50 values of 19 nM and 47 nM, respectively. It is widely used in cancer research, demonstrating antitumor activity in both in vitro cellular assays and in vivo models of various malignancies.
CAS Number
923032-37-5
Product Name Alternative
Tumor, RDEA119, RDEA-119, Refametinib, RDEA 119, MAP2K, MAPKK, MEK, MEK1, MEK2, Inhibitor, inhibit, Mitogen-activated protein kinase kinase, orally, BAY 869766, BAY 86-97661, BAY869766, BAY-869766, allosteric
Field of Research
Signal Transduction
Purity
99.53% (May vary between batches)
Solubility
Ethanol:93 mg/mL (162.49 mM) ; DMSO:150 mg/mL (262.08 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
S (NC1=C (NC2=C (F) C=C (I) C=C2) C (F) =C (F) C=C1OC) (=O) (=O) C3 (C[C@@H] (CO) O) CC3
Molecular Formula
C19H20F3IN2O5S
Molecular Weight
572.34
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Refametinib

Refametinib is an orally bioavailable selective MEK inhibitor with potential antineoplastic activity. Refametinib specifically inhibits mitogen-activated protein kinase kinase 1 (MAP2K1 or MAPK/ERK kinase 1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation.

CAS Number923032-37-5
PubChem CID44182295
IUPAC NameN-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropane-1-sulfonamide
Molecular FormulaC19H20F3IN2O5S
Molecular Weight572.3
XLogP2.8
Topological Polar Surface Area116
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count10
Rotatable Bond Count9
Heavy Atom Count31
Formal Charge0
Complexity711
SMILES
COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)C[C@@H](CO)O)NC3=C(C=C(C=C3)I)F)F)F
InChI
InChI=1S/C19H20F3IN2O5S/c1-30-15-7-13(21)16(22)18(24-14-3-2-10(23)6-12(14)20)17(15)25-31(28,29)19(4-5-19)8-11(27)9-26/h2-3,6-7,11,24-27H,4-5,8-9H2,1H3/t11-/m0/s1
InChIKey
RDSACQWTXKSHJT-NSHDSACASA-N
Chemical Structure
2D Structure
2D structure of Refametinib
CAS: 923032-37-5
CID: 44182295
Formula: C19H20F3IN2O5S
MW: 572.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight572.3
XLogP32.8
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count10
Rotatable Bond Count9
Exact Mass572.00897
Monoisotopic Mass572.00897
Topological Polar Surface Area116 Ų
Heavy Atom Count31
Formal Charge0
Complexity711
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B1267-5Refametinib
MBS131587-01Refametinib?RDEA119)
A11264-100Refametinib 100mg
C07506-01Refametinib (RDEA119)
A11264-10Refametinib 10mg
A11264-5Refametinib 5mg
A11264-2Refametinib 2mg
HY-14691R-01Refametinib (Standard)
A11264-50Refametinib 50mg

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