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Refametinib

CAT: 0013-GTR19169740-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169740-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Refametinib (RDEA119) is a potent and selective, ATP-noncompetitive inhibitor of MEK1 and MEK2 kinases, exhibiting IC50 values of 19 nM and 47 nM, respectively. It is widely used in cancer research, demonstrating antitumor activity in both in vitro cellular assays and in vivo models of various malignancies.
CAS Number
923032-37-5
Product Name Alternative
Tumor, RDEA119, RDEA-119, Refametinib, RDEA 119, MAP2K, MAPKK, MEK, MEK1, MEK2, Inhibitor, inhibit, Mitogen-activated protein kinase kinase, orally, BAY 869766, BAY 86-97661, BAY869766, BAY-869766, allosteric
Field of Research
Signal Transduction
Purity
99.53% (May vary between batches)
Solubility
Ethanol:93 mg/mL (162.49 mM) ; DMSO:150 mg/mL (262.08 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
S (NC1=C (NC2=C (F) C=C (I) C=C2) C (F) =C (F) C=C1OC) (=O) (=O) C3 (C[C@@H] (CO) O) CC3
Molecular Formula
C19H20F3IN2O5S
Molecular Weight
572.34
Storage Conditions
-20°C
Notes
For research use only.

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B1267-5Refametinib
MBS131587-01Refametinib?RDEA119)
A11264-100Refametinib 100mg
C07506-01Refametinib (RDEA119)
A11264-10Refametinib 10mg
A11264-5Refametinib 5mg
A11264-2Refametinib 2mg
HY-14691R-01Refametinib (Standard)
A11264-50Refametinib 50mg

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