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ARN-3236

CAT: 0013-GTR19168950-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19168950-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ARN-3236 is a potent, orally bioavailable, and selective salt-inducible kinase 2 (SIK2) inhibitor, with IC50 values of <1 nM, 21.63 nM, and 6.63 nM for SIK2, SIK1, and SIK3, respectively. This small molecule exhibits anti-cancer activity and is a valuable research tool for studying SIK2 signaling in both in vitro cellular assays and in vivo cancer models.
CAS Number
1613710-01-2
Product Name Alternative
ARN3236, ARN-3236, ARN 3236, inhibit, Inhibitor, Salt-inducible Kinase (SIK), SIK2
Field of Research
Epigenetics & Chromatin, Signal Transduction
Purity
98.89% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.89 mM) ; DMSO:130 mg/mL (386.43 mM)
Smiles
COc1ccc (-c2c[nH]c3nccc (-c4ccsc4) c23) c (OC) c1
Molecular Formula
C19H16N2O2S
Molecular Weight
336.41
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

3-(2,4-dimethoxyphenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine
CAS Number1613710-01-2
PubChem CID74766530
IUPAC Name3-(2,4-dimethoxyphenyl)-4-thiophen-3-yl-1H-pyrrolo[2,3-b]pyridine
Molecular FormulaC19H16N2O2S
Molecular Weight336.4
XLogP4.2
Topological Polar Surface Area75.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count24
Formal Charge0
Complexity424
SMILES
COC1=CC(=C(C=C1)C2=CNC3=NC=CC(=C23)C4=CSC=C4)OC
InChI
InChI=1S/C19H16N2O2S/c1-22-13-3-4-15(17(9-13)23-2)16-10-21-19-18(16)14(5-7-20-19)12-6-8-24-11-12/h3-11H,1-2H3,(H,20,21)
InChIKey
WEHOIIGXTMKVRG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(2,4-dimethoxyphenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine
CAS: 1613710-01-2
CID: 74766530
Formula: C19H16N2O2S
MW: 336.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight336.4
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass336.09324893
Monoisotopic Mass336.09324893
Topological Polar Surface Area75.4 Ų
Heavy Atom Count24
Formal Charge0
Complexity424
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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A4680-10ARN-3236
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A18725-2ARN-3236 2mg
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A18725-100ARN-3236 100mg
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