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Glaucine

CAT: 0013-GTR19168834-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19168834-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Glaucine is a natural alkaloid with demonstrated antitussive, antioxidant, and antiviral properties. Research indicates it exhibits anti-arthritic potential and modulates immune responses by enhancing IL-10 production. In vitro studies show it inhibits breast cancer cell migration and invasion via suppression of MMP-9 and the NF-κB pathway.
CAS Number
475-81-0
Product Name Alternative
Glaucine, Inhibitor, InfluenzaVirus, Influenza Virus, inhibit, NSC 34396, NSC34396, NSC-34396, O, O-Dimethylisoboldine, PDE4, Adrenergic Receptor, AdrenergicReceptor, alkaloid, anti-arthritic, antioxidative, anti-inflammatory, antitussive, antiviral, Ca channels, Ca2+, cAMP, Ca2+ channels, Calcium Channel, bronchodilation, DopamineReceptor, Dopamine, Dopamine Receptor, Beta Receptor, CalciumChannel, Phosphodiesterase (PDE), phosphodiesterase, α-adrenoceptor
Field of Research
Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.63 mM) ; DMSO:30 mg/mL (84.4 mM)
Smiles
O (C) C1=C2C=3[C@] (CC=4C2=CC (OC) =C (OC) C4) (N (C) CCC3C=C1OC) [H]
Molecular Formula
C21H25NO4
Molecular Weight
355.43
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(+)-Glaucine

(S)-glaucine is an aporphine alkaloid that is (S)-1,2,9,10-tetrahydroxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline in which the four phenolic hydrogens have been replaced by methyl groups. It has a role as an antibacterial agent, an antineoplastic agent, a platelet aggregation inhibitor, an antitussive, a muscle relaxant, a NF-kappaB inhibitor, a plant metabolite and a rat metabolite. It is an aporphine alkaloid, an organic heterotetracyclic compound, a polyether and a tertiary amino compound. It is a conjugate base of a (S)-glaucine(1+).

CAS Number475-81-0
PubChem CID16754
IUPAC Name(6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
Molecular FormulaC21H25NO4
Molecular Weight355.4
XLogP3.4
Topological Polar Surface Area40.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count26
Formal Charge0
Complexity489
SMILES
CN1CCC2=CC(=C(C3=C2[C@@H]1CC4=CC(=C(C=C43)OC)OC)OC)OC
InChI
InChI=1S/C21H25NO4/c1-22-7-6-12-9-18(25-4)21(26-5)20-14-11-17(24-3)16(23-2)10-13(14)8-15(22)19(12)20/h9-11,15H,6-8H2,1-5H3/t15-/m0/s1
InChIKey
RUZIUYOSRDWYQF-HNNXBMFYSA-N
Chemical Structure
2D Structure
2D structure of (+)-Glaucine
CAS: 475-81-0
CID: 16754
Formula: C21H25NO4
MW: 355.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight355.4
XLogP33.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass355.17835828
Monoisotopic Mass355.17835828
Topological Polar Surface Area40.2 Ų
Heavy Atom Count26
Formal Charge0
Complexity489
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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