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Glaucine (Standard)

CAT: 0804-HY-N3945RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N3945RSize:1 Each
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Description
Glaucine (Standard) is the analytical standard of Glaucine. This product is intended for research and analytical applications. Glaucine (O, O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 μM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities[1][2][3].
CAS Number
475-81-0
Product Name Alternative
O, O-Dimethylisoboldine (Standard) ; S- (+) -Glaucine (Standard) ; NSC 34396 (Standard)
UNSPSC
12352005
Target
Adrenergic Receptor; Calcium Channel; Dopamine Receptor; Influenza Virus; Phosphodiesterase (PDE) ; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/glaucine-standard.html
Smiles
CN1CCC2=CC(OC)=C(OC)C3=C2[C@]1([H])CC4=CC(OC)=C(OC)C=C34
Molecular Formula
C21H25NO4
Molecular Weight
355.43
References & Citations
[1]J Cortijo, et al. Bronchodilator and Anti-Inflammatory Activities of Glaucine: In Vitro Studies in Human Airway Smooth Muscle and Polymorphonuclear Leukocytes. Br J Pharmacol. 1999 Aug;127 (7) :1641-51.|[2]Golo M J Meyer, et al. Studies on the in Vivo Contribution of Human Cytochrome P450s to the Hepatic Metabolism of Glaucine, a New Drug of Abuse. Biochem Pharmacol. 2013 Nov 15;86 (10) :1497-506.|[3]Maya Spasova, et al. Cinnamoyl- And Hydroxycinnamoyl Amides of Glaucine and Their Antioxidative and Antiviral Activities. Bioorg Med Chem. 2008 Aug 1;16 (15) :7457-61.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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