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NRX-1933

CAT: 0013-GTR19168779-06Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19168779-06Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NRX-1933 is a molecular glue degrader that stabilizes the interaction between oncogenic β-Catenin and the SCFβ-TrCP E3 ligase, promoting β-Catenin's ubiquitination and degradation. This tool compound is used in vitro and in vivo to study Wnt/β-catenin signaling in cancer and regenerative biology research.
CAS Number
2763260-30-4
Product Name Alternative
Inhibitor, NRX 1933, NRX1933, NRX-1933, inhibit
Field of Research
Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.79% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:3.3 mg/mL (9.42 mM) ; DMSO:80 mg/mL (228.4 mM)
Smiles
FC (F) (F) c1ccc (C (=O) Nc2cccc (c2) -c2nn[nH]n2) c (=O) [nH]1
Molecular Formula
C14H9F3N6O2
Molecular Weight
350.26
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

2-oxo-N-[3-(2H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)-1H-pyridine-3-carboxamide
CAS Number2763260-30-4
PubChem CID137628322
IUPAC Name2-oxo-N-[3-(2H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)-1H-pyridine-3-carboxamide
Molecular FormulaC14H9F3N6O2
Molecular Weight350.26
XLogP1.4
Topological Polar Surface Area113
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity618
SMILES
C1=CC(=CC(=C1)NC(=O)C2=CC=C(NC2=O)C(F)(F)F)C3=NNN=N3
InChI
InChI=1S/C14H9F3N6O2/c15-14(16,17)10-5-4-9(13(25)19-10)12(24)18-8-3-1-2-7(6-8)11-20-22-23-21-11/h1-6H,(H,18,24)(H,19,25)(H,20,21,22,23)
InChIKey
IAVMZDPIQIVLOG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-oxo-N-[3-(2H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)-1H-pyridine-3-carboxamide
CAS: 2763260-30-4
CID: 137628322
Formula: C14H9F3N6O2
MW: 350.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight350.26
XLogP31.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass350.07390804
Monoisotopic Mass350.07390804
Topological Polar Surface Area113 Ų
Heavy Atom Count25
Formal Charge0
Complexity618
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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