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VU0364770

CAT: 0013-GTR19168138-01Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19168138-01Size:1 ml x 10 mM (in DMSO)
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Description
VU0364770 is a selective positive allosteric modulator (PAM) of the mGlu4 receptor with an EC50 of 1.1 μM, demonstrating negligible activity at 68 other tested receptors. This selectivity makes it a valuable research tool for investigating mGlu4's role in neurological disorders, including Parkinson's disease, in both in vitro and in vivo models.
CAS Number
61350-00-3
Product Name Alternative
Inhibitor, inhibit, mGluR, mGluR4, Metabotropic glutamate receptors, VU0364770, VU-0364770, VU 0364770
Field of Research
Neuroscience
Purity
99.65% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.6 mM) ; DMSO:50 mg/mL (214.9 mM)
Smiles
Clc1cccc (NC (=O) c2ccccn2) c1
Molecular Formula
C12H9ClN2O
Molecular Weight
232.67
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

VU0364770
CAS Number61350-00-3
PubChem CID836002
IUPAC NameN-(3-chlorophenyl)pyridine-2-carboxamide
Molecular FormulaC12H9ClN2O
Molecular Weight232.66
XLogP2.6
Topological Polar Surface Area42
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count16
Formal Charge0
Complexity247
SMILES
C1=CC=NC(=C1)C(=O)NC2=CC(=CC=C2)Cl
InChI
InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)
InChIKey
SUYUTNCKIOLMAJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of VU0364770
CAS: 61350-00-3
CID: 836002
Formula: C12H9ClN2O
MW: 232.66
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight232.66
XLogP32.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass232.0403406
Monoisotopic Mass232.0403406
Topological Polar Surface Area42 Ų
Heavy Atom Count16
Formal Charge0
Complexity247
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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