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VU0364770 (Standard)

CAT: 0804-HY-100588RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100588RSize:1 Each
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Description
VU0364770 (Standard) is the analytical standard of VU0364770. This product is intended for research and analytical applications. VU0364770 is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 exhibits EC50s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 also possesses activity at MAO with Ki values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively[1].
CAS Number
61350-00-3
Target
MGluR; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
O=C(C1=NC=CC=C1)NC2=CC=CC(Cl)=C2
Molecular Formula
C12H9ClN2O
Molecular Weight
232.67
References & Citations
[1]Jones CK, et al. The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. J Pharmacol Exp Ther. 2012 Feb;340 (2) :404-21.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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