WYE-354

• Target :

  PI3K|||Apoptosis|||mTOR|||Autophagy

• Related Pathways :

  Apoptosis|||PI3K/Akt/mTOR signaling|||Autophagy

• Purity :

  0.9961

• Bioactivity :

  WYE-354 (IC50=5 nM) is an effective, selective and ATP-competitive mTOR inhibitor. It blocks mTORC2/P-AKT (S473) and mTORC1/P-S6K (T389), not P-AKT (T308) . The selectivity for mTOR is higher than PI3K? (>100-fold) and PI3K? (>500-fold) .

• Smiles :

  COC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)OC)c2n1

• Molecular Formula :

  C24H29N7O5

• Molecular Weight :

  495.53

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1062169-56-5