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WYE-354

CAT: 0931-T6731-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T6731-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1062169-56-5
Target
PI3K|||Apoptosis|||mTOR|||Autophagy
Related Pathways
Apoptosis|||PI3K/Akt/mTOR signaling|||Autophagy
Purity
0.9961
Bioactivity
WYE-354 (IC50=5 nM) is an effective, selective and ATP-competitive mTOR inhibitor. It blocks mTORC2/P-AKT (S473) and mTORC1/P-S6K (T389), not P-AKT (T308) . The selectivity for mTOR is higher than PI3K? (>100-fold) and PI3K? (>500-fold) .
Smiles
COC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)OC)c2n1
Molecular Formula
C24H29N7O5
Molecular Weight
495.53
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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MBS3600274-01WYE-354
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