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BMS-911543

CAT: 0013-GTR19168075-03Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19168075-03Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMS-911543 is a highly selective JAK2 inhibitor (IC50 = 1.1 nM) with significant selectivity over JAK1, JAK3, and TYK2. It is a valuable research tool for investigating JAK2-dependent pathways in myeloproliferative neoplasms and hematological malignancies, as evidenced in both in vitro and in vivo preclinical studies.
CAS Number
1271022-90-2
Product Name Alternative
SET-2, Tyrosine Kinases, TyrosineKinases, TYK2, BMS 911543, BMS911543, BMS-911543, Inhibitor, HistoneMethyltransferase, Histone Methyltransferase, JAK3, Janus kinase, JAK2, JAK, JAK1, inhibit
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
97.69% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.62 mM) ; DMSO:34 mg/mL (78.61 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:21 mg/mL (48.55 mM)
Smiles
CCn1c (cc2c1nc (Nc1cc (C) n (C) n1) c1ncn (C) c21) C (=O) N (C1CC1) C1CC1
Molecular Formula
C23H28N8O
Molecular Weight
432.52
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Bms-911543

BMS-911543 has been used in trials studying the treatment of Cancer.

CAS Number1271022-90-2
PubChem CID50922691
IUPAC NameN,N-dicyclopropyl-7-[(1,5-dimethylpyrazol-3-yl)amino]-10-ethyl-3-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene-11-carboxamide
Molecular FormulaC23H28N8O
Molecular Weight432.5
XLogP2.9
Topological Polar Surface Area85.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count32
Formal Charge0
Complexity717
SMILES
CCN1C(=CC2=C3C(=C(N=C21)NC4=NN(C(=C4)C)C)N=CN3C)C(=O)N(C5CC5)C6CC6
InChI
InChI=1S/C23H28N8O/c1-5-30-17(23(32)31(14-6-7-14)15-8-9-15)11-16-20-19(24-12-28(20)3)21(26-22(16)30)25-18-10-13(2)29(4)27-18/h10-12,14-15H,5-9H2,1-4H3,(H,25,26,27)
InChIKey
JCINBYQJBYJGDM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Bms-911543
CAS: 1271022-90-2
CID: 50922691
Formula: C23H28N8O
MW: 432.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight432.5
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass432.23860755
Monoisotopic Mass432.23860755
Topological Polar Surface Area85.8 Ų
Heavy Atom Count32
Formal Charge0
Complexity717
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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