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GSK481

CAT: 0013-GTR19168020-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19168020-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK481 is a potent and selective small molecule inhibitor of RIP1 kinase (RIPK1) . It is a valuable research tool for investigating necroptosis in cellular and animal models, aiding the study of inflammatory and degenerative diseases.
CAS Number
1622849-58-4
Product Name Alternative
Inhibit, Inhibitor, GSK481, GSK'481, GSK-481, GSK 481, RIP kinase, RIPK, RIP1, RIPkinase, Receptor-interacting protein kinases
Field of Research
Cell Biology, Signal Transduction
Purity
98.97% (May vary between batches)
Solubility
DMSO:70 mg/mL (185.48 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.3 mM)
Smiles
CN1c2ccccc2OC[C@H] (NC (=O) c2cc (Cc3ccccc3) on2) C1=O
Molecular Formula
C21H19N3O4
Molecular Weight
377.39
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Gsk481
CAS Number1622849-58-4
PubChem CID90351311
IUPAC Name5-benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide
Molecular FormulaC21H19N3O4
Molecular Weight377.4
XLogP2.8
Topological Polar Surface Area84.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count28
Formal Charge0
Complexity566
SMILES
CN1C2=CC=CC=C2OC[C@@H](C1=O)NC(=O)C3=NOC(=C3)CC4=CC=CC=C4
InChI
InChI=1S/C21H19N3O4/c1-24-18-9-5-6-10-19(18)27-13-17(21(24)26)22-20(25)16-12-15(28-23-16)11-14-7-3-2-4-8-14/h2-10,12,17H,11,13H2,1H3,(H,22,25)/t17-/m0/s1
InChIKey
KNOUWGGQMADIBV-KRWDZBQOSA-N
Chemical Structure
2D Structure
2D structure of Gsk481
CAS: 1622849-58-4
CID: 90351311
Formula: C21H19N3O4
MW: 377.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight377.4
XLogP32.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass377.13755610
Monoisotopic Mass377.13755610
Topological Polar Surface Area84.7 Ų
Heavy Atom Count28
Formal Charge0
Complexity566
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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B6194-2GSK481
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