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Rhynchophylline

CAT: 0013-GTR19167842-02Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19167842-02Size:1 ml x 10 mM (in DMSO)
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Description
Rhynchophylline is a neuroprotective alkaloid that acts as a non-competitive NMDA receptor antagonist. It has demonstrated protective effects against ischemic damage and glutamate-induced neuronal death in vitro, potentially via modulation of the Akt/mTOR pathway, and is used in neuroscience research.
CAS Number
76-66-4
Product Name Alternative
Calcium Channel, CalciumChannel, inhibit, Mitrinermin, Mitrinermine, NF-κB, NFkB, NF-kB, NFκB, Nuclear factor-κB, Nuclear factor-kappaB, Inhibitor, Rhynchophyllin, Rhynchophylline, Rhyncophylline
Field of Research
Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
99.44% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.2 mM) ; DMSO:28.06 mg/mL (72.98 mM)
Smiles
CCC1CN2CCC3 (C2CC1C (=COC) C (=O) OC) C (=O) Nc1ccccc31
Molecular Formula
C22H28N2O4
Molecular Weight
384.47
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Rhynchophylline

Rhynchophylline is a member of indolizines. It has a role as a metabolite.

CAS Number76-66-4
PubChem CID5281408
IUPAC Namemethyl (E)-2-[(3R,6'R,7'S,8'aS)-6'-ethyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate
Molecular FormulaC22H28N2O4
Molecular Weight384.5
XLogP2.3
Topological Polar Surface Area67.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count28
Formal Charge0
Complexity663
SMILES
CC[C@H]1CN2CC[C@]3([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)C4=CC=CC=C4NC3=O
InChI
InChI=1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22+/m0/s1
InChIKey
DAXYUDFNWXHGBE-KAXDATADSA-N
Chemical Structure
2D Structure
2D structure of Rhynchophylline
CAS: 76-66-4
CID: 5281408
Formula: C22H28N2O4
MW: 384.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight384.5
XLogP32.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass384.20490738
Monoisotopic Mass384.20490738
Topological Polar Surface Area67.9 Ų
Heavy Atom Count28
Formal Charge0
Complexity663
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-N0387-01Rhynchophylline
HY-N0387R-01Rhynchophylline (Standard)
371913Rhynchophylline discontinued
BR300119Rhynchophylline - Bio-X TM

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