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Rhynchophylline

CAT: 0931-T6S0659-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T6S0659-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
76-66-4
Target
NF-κB, Calcium Channel
Related Pathways
Membrane transporter/Ion channel, Metabolism, NF-κB
Purity
0.9998
Bioactivity
1. Rhynchophylline (Mitrinermine) can protect against ischemic damage, probably via regulating the Akt/mTOR pathway. 2. Rhynchophylline can protect against glutamate-induced neuronal death, can inhibit MA impairment in cultured neurons in vitro. 3. Rhynchophylline and isorhynchophylline have a non-competitive antagonistic effect on the NMDA-type ionotropic glutamate receptors, suggest that these alkaloids exert their protective action against ischemia-induced neuronal damage by preventing NMDA, muscarinic M1, and 5-HT2 receptors-mediated neurotoxicity during ischemia.
Smiles
CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C(=O)Nc1ccccc31
Molecular Formula
C22H28N2O4
Molecular Weight
384.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C