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WS-12

CAT: 0013-GTR19167629-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19167629-06Size:100 mg
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Description
WS-12 is a high-potency, selective agonist of the TRPM8 ion channel, eliciting a robust cooling sensation with an EC50 of 193 nM. This small molecule is a valuable research tool for studying thermosensation, pain pathways, and channel pharmacology in both cellular and animal models.
CAS Number
68489-09-8
Product Name Alternative
TRP Channel, TRPChannel, TRPM8, TRPV Channel, TRPVChannel, Transient receptor potential channels, WS12, WS-12, WS 12, HEK293T, Inhibitor, inhibit, cultured mouse DRG neurons, chronic neuropathic pain, AVX 012, AVX012, AVX-012, AR15512, AR-15512, AR 15512, analgesic effect
Field of Research
Pharmacology & Drug Discovery
Purity
99.71% (May vary between batches)
Solubility
DMSO:50 mg/mL (172.77 mM) ;10% DMSO+90% Corn Oil:2.5 mg/mL (8.64 mM)
Smiles
C (NC1=CC=C (OC) C=C1) (=O) [C@H]2[C@H] ([C@H] (C) C) CC[C@@H] (C) C2
Molecular Formula
C18H27NO2
Molecular Weight
289.41
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

AR-15512

Acoltremon is under investigation in clinical trial NCT05493111 (A Long-term Safety Study Evaluating the Safety and Systemic Exposure of AR-15512).

CAS Number68489-09-8
PubChem CID11266244
IUPAC Name(1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide
Molecular FormulaC18H27NO2
Molecular Weight289.4
XLogP4.6
Topological Polar Surface Area38.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Heavy Atom Count21
Formal Charge0
Complexity334
SMILES
C[C@@H]1CC[C@H]([C@@H](C1)C(=O)NC2=CC=C(C=C2)OC)C(C)C
InChI
InChI=1S/C18H27NO2/c1-12(2)16-10-5-13(3)11-17(16)18(20)19-14-6-8-15(21-4)9-7-14/h6-9,12-13,16-17H,5,10-11H2,1-4H3,(H,19,20)/t13-,16+,17-/m1/s1
InChIKey
HNSGVPAAXJJOPQ-XOKHGSTOSA-N
Chemical Structure
2D Structure
2D structure of AR-15512
CAS: 68489-09-8
CID: 11266244
Formula: C18H27NO2
MW: 289.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight289.4
XLogP34.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass289.204179104
Monoisotopic Mass289.204179104
Topological Polar Surface Area38.3 Ų
Heavy Atom Count21
Formal Charge0
Complexity334
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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