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4-IPP

CAT: 0013-GTR19167348-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19167348-01Size:2 mg
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Description
4-Iodo-6-phenylpyrimidine (4-IPP) is a potent, irreversible inhibitor of the cytokine macrophage migration inhibitory factor (MIF) . It is widely used in biochemical and cellular research to study MIF's role in inflammatory diseases, cancer, and autoimmune conditions, both in vitro and in animal models.
CAS Number
41270-96-6
Product Name Alternative
4 IPP, 4-Iodo-6-phenylpyrimidine, 4IPP, 4-IPP, inhibit, osteoclastogenesis, osteoblast, MIF, Inhibitor, RANKL
Field of Research
Immunology & Inflammation, Musculoskeletal & Connective Tissue Research
Purity
99.43% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.09 mM) ; DMSO:122.5 mg/mL (434.27 mM)
Smiles
Ic1cc (ncn1) -c1ccccc1
Molecular Formula
C10H7IN2
Molecular Weight
282.08
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

4-Iodo-6-phenylpyrimidine

4-iodo-6-phenylpyrimidine is a member of the class of pyrimidines carrying iodo and phenyl substituents at positions 4 and 6 respectively. It has a role as an antineoplastic agent, an apoptosis inducer and a macrophage migration inhibitory factor inhibitor. It is an organoiodine compound, a member of pyrimidines and a biaryl.

CAS Number41270-96-6
PubChem CID817368
IUPAC Name4-iodo-6-phenylpyrimidine
Molecular FormulaC10H7IN2
Molecular Weight282.08
XLogP2.6
Topological Polar Surface Area25.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count13
Formal Charge0
Complexity157
SMILES
C1=CC=C(C=C1)C2=CC(=NC=N2)I
InChI
InChI=1S/C10H7IN2/c11-10-6-9(12-7-13-10)8-4-2-1-3-5-8/h1-7H
InChIKey
ZTCJXHNJVLUUMR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-Iodo-6-phenylpyrimidine
CAS: 41270-96-6
CID: 817368
Formula: C10H7IN2
MW: 282.08
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight282.08
XLogP32.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass281.96540
Monoisotopic Mass281.96540
Topological Polar Surface Area25.8 Ų
Heavy Atom Count13
Formal Charge0
Complexity157
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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