4-IPP

• Description:

  4-IPP (4-Iodo-6-phenylpyrimidine) is a specific suicide substrate and irreversible inhibitor of macrophage migration inhibitory factor (MIF) [1].

• Product Name Alternative:

  4-Iodo-6-phenylpyrimidine

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H318, H335

• Target:

  Macrophage migration inhibitory factor (MIF)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/4-ipp.html

• Purity:

  99.46

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  IC1=CC(C2=CC=CC=C2)=NC=N1

• Molecular Formula:

  C10H7IN2

• Molecular Weight:

  282.08

• Precautions:

  H302, H315, H318, H335

• References & Citations:

  [1]Zheng L, et al. Macrophage migration inhibitory factor (MIF) inhibitor 4-IPP suppresses osteoclast formation and promotes osteoblast differentiation through the inhibition of the NF-κB signaling pathway. FASEB J. 2019 Jun;33 (6) :7667-7683.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [41270-96-6]