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Derenofylline

CAT: 0013-GTR19167128-04Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19167128-04Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Derenofylline is a potent and selective adenosine A1 receptor antagonist, exhibiting a Ki value of 1 nM in vitro. It is a valuable research tool for investigating adenosine signaling in fields such as renal physiology, cardiac ischemia, and central nervous system disorders, with utility in both in vitro and in vivo experimental models.
CAS Number
251945-92-3
Product Name Alternative
Cardiomyopathy, Derenofylline, AdenosineReceptor, Adenosine Receptor, A1, fibrosis, Inhibitor, inhibit, Nephrectomy, P1 receptor, SLV 320, SLV320, SLV-320, uraemic
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.09% (May vary between batches)
Solubility
DMSO:22.5 mg/mL (72.96 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (16.21 mM)
Smiles
O[C@H]1CC[C@@H] (CC1) Nc1nc (nc2[nH]ccc12) -c1ccccc1
Molecular Formula
C18H20N4O
Molecular Weight
308.38
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Slv320

Derenofylline has been used in trials studying the treatment of Congestive Heart Failure and Acute Decompensated Heart Failure; Renal Dysfunction.

CAS Number251945-92-3
PubChem CID9953065
IUPAC Name4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexan-1-ol
Molecular FormulaC18H20N4O
Molecular Weight308.4
XLogP3.3
Topological Polar Surface Area73.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count23
Formal Charge0
Complexity379
SMILES
C1CC(CCC1NC2=NC(=NC3=C2C=CN3)C4=CC=CC=C4)O
InChI
InChI=1S/C18H20N4O/c23-14-8-6-13(7-9-14)20-18-15-10-11-19-17(15)21-16(22-18)12-4-2-1-3-5-12/h1-5,10-11,13-14,23H,6-9H2,(H2,19,20,21,22)
InChIKey
RBZNJGHIKXAKQE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Slv320
CAS: 251945-92-3
CID: 9953065
Formula: C18H20N4O
MW: 308.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight308.4
XLogP33.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass308.16371127
Monoisotopic Mass308.16371127
Topological Polar Surface Area73.8 Ų
Heavy Atom Count23
Formal Charge0
Complexity379
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T8312-01Derenofylline
C07087-5mgDerenofylline (SLV320)
HY-14858RDerenofylline (Standard)
A21990-25Derenofylline 25mg
A21990-50Derenofylline 50mg
A21990-200Derenofylline 200mg
A21990-100Derenofylline 100mg
A21990-10Derenofylline 10mg
A21990-5Derenofylline 5mg
A21990-10mM-DDerenofylline 10mM * 1mL in DMSO

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