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Derenofylline (Standard)

CAT: 0804-HY-14858RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14858RSize:1 Each
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Description
Derenofylline (Standard) is the analytical standard of Derenofylline. This product is intended for research and analytical applications. Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats[1].
CAS Number
251945-92-3
UNSPSC
12352100
Target
Adenosine Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Others
Field of Research
Cardiovascular Disease
Smiles
O[C@H]1CC[C@H](NC2=C3C(NC=C3)=NC(C4=CC=CC=C4)=N2)CC1
Molecular Formula
C18H20N4O
Molecular Weight
308.38
References & Citations
[1]Kalk P, et al. The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure. Br J Pharmacol. 2007 Aug;151 (7) :1025-32.|[2]Marta Mateus, et al. Understanding the Role of Adenosine Receptors in the Myofibroblast Transformation in Peyronie's Disease. J Sex Med. 2018 Jul;15 (7) :947-957.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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T8312-01Derenofylline
C07087-5mgDerenofylline (SLV320)
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A21990-200Derenofylline 200mg
A21990-100Derenofylline 100mg
A21990-10Derenofylline 10mg
A21990-5Derenofylline 5mg
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abx098968-01Standard

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