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MNK8

CAT: 0013-GTR19166686-05Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19166686-05Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MNK8 is a potent and selective STAT3 inhibitor that disrupts STAT3-DNA binding. It demonstrates robust anti-proliferative activity against liver cancer cells in vitro and has shown efficacy in reducing tumor growth in vivo models of hepatocellular carcinoma.
CAS Number
2055078-49-2
Product Name Alternative
Antimigratory agent, Anticancer, Apoptosis, Bcl-2 Family, 3-methyl-6- (naphthalen-1-yl) pyrimidine-2,4 (1H,3H) -dione, MNK8, MNK-8, MNK8 , MNK 8, N-methyluracil derivatives, inhibit, HCC cells, hepatocellular carcinoma, HepG2, Inhibitor, Survivin, STAT3 inhibitor, STAT, STAT3
Field of Research
Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.74% (May vary between batches)
Solubility
DMSO:55 mg/mL (218.02 mM)
Smiles
O=C1C=C (C=2C3=C (C=CC2) C=CC=C3) NC (=O) N1C
Molecular Formula
C15H12N2O2
Molecular Weight
252.27
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

3-Methyl-6-(1-naphthalenyl)-2,4(1H,3H)-pyrimidinedione
CAS Number2055078-49-2
PubChem CID164517038
IUPAC Name3-methyl-6-naphthalen-1-yl-1H-pyrimidine-2,4-dione
Molecular FormulaC15H12N2O2
Molecular Weight252.27
XLogP2.1
Topological Polar Surface Area49.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count19
Formal Charge0
Complexity430
SMILES
CN1C(=O)C=C(NC1=O)C2=CC=CC3=CC=CC=C32
InChI
InChI=1S/C15H12N2O2/c1-17-14(18)9-13(16-15(17)19)12-8-4-6-10-5-2-3-7-11(10)12/h2-9H,1H3,(H,16,19)
InChIKey
SJRMGNRXVMMJSY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-Methyl-6-(1-naphthalenyl)-2,4(1H,3H)-pyrimidinedione
CAS: 2055078-49-2
CID: 164517038
Formula: C15H12N2O2
MW: 252.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight252.27
XLogP32.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass252.089877630
Monoisotopic Mass252.089877630
Topological Polar Surface Area49.4 Ų
Heavy Atom Count19
Formal Charge0
Complexity430
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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