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O-Nornuciferine

CAT: 0013-GTR19166702-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19166702-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
O-Nornuciferine is a small molecule that potently blocks the hERG potassium channel in vitro, with an IC50 of 2.89 μM in HEK293 cells. This aporphine alkaloid is used in cardiovascular safety pharmacology and electrophysiology research to study compound-induced arrhythmia risks.
CAS Number
3153-55-7
Product Name Alternative
KcsA, inhibit, Inhibitor, O Nornuciferine, ONornuciferine, O-Nornuciferine, hERG, PotassiumChannel, Potassium Channel
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
99.86% (May vary between batches)
Solubility
DMSO:50 mg/mL (177.71 mM)
Smiles
[H][C@]12Cc3ccccc3-c3c (OC) c (O) cc (CCN1C) c23
Molecular Formula
C18H19NO2
Molecular Weight
281.35
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.

Chemical Information

(-)-Nornuciferine

O-Nornuciferine has been reported in Stephania cephalantha, Ziziphus jujuba, and other organisms with data available.

CAS Number3153-55-7
PubChem CID197017
IUPAC Name(6aR)-1-methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-2-ol
Molecular FormulaC18H19NO2
Molecular Weight281.3
XLogP2.6
Topological Polar Surface Area32.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count21
Formal Charge0
Complexity387
SMILES
CN1CCC2=CC(=C(C3=C2[C@H]1CC4=CC=CC=C43)OC)O
InChI
InChI=1S/C18H19NO2/c1-19-8-7-12-10-15(20)18(21-2)17-13-6-4-3-5-11(13)9-14(19)16(12)17/h3-6,10,14,20H,7-9H2,1-2H3/t14-/m1/s1
InChIKey
AKXOIHNFHOEPHN-CQSZACIVSA-N
Chemical Structure
2D Structure
2D structure of (-)-Nornuciferine
CAS: 3153-55-7
CID: 197017
Formula: C18H19NO2
MW: 281.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight281.3
XLogP32.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass281.141578849
Monoisotopic Mass281.141578849
Topological Polar Surface Area32.7 Ų
Heavy Atom Count21
Formal Charge0
Complexity387
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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