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Ningetinib Tosylate

CAT: 0013-GTR19166347-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19166347-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ningetinib Tosylate is a potent, orally active small molecule inhibitor targeting Axl, VEGFR2, and c-Met kinases with IC50 values below 10 nM. It is utilized in preclinical cancer research, particularly in studies involving tumor angiogenesis, metastasis, and resistance mechanisms in both cellular and animal models.
CAS Number
1394820-77-9
Product Name Alternative
CMet, c-Met, cMet/HGFR, c-Met/HGFR, AXL, Axl, HGFR, Mer, inhibit, Inhibitor, Ningetinib, Ningetinib Tosylate, TAM Receptor, TAMReceptor, Vascular endothelial growth factor receptor, VEGFR, VEGFR2, Tyro3
Field of Research
Cardiovascular Research, Signal Transduction
Purity
99.77% (May vary between batches)
Solubility
DMSO:8 mg/mL (10.98 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.37 mM)
Smiles
Cc1ccc (cc1) S (O) (=O) =O.Cc1c (C (=O) Nc2ccc (Oc3ccnc4cc (OCC (C) (C) O) ccc34) c (F) c2) c (=O) n (-c2ccccc2) n1C
Molecular Formula
C38H37FN4O8S
Molecular Weight
728.79
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.

Chemical Information

Ningetinib Tosylate

Ningetinib Tosylate is the tosylate salt form of ningetinib, an orally available inhibitor of the receptor tyrosine kinases c-MET/hepatocyte growth factor receptor (HGFR), vascular endothelial growth factor receptor 2 (VEGFR2 KDR), Axl (UFO), Mer, and Fms-like tyrosine kinase 3 (Flt3; CD135; STK1; FLK2), with antineoplastic activity. Upon administration, ningetinib binds to a variety of kinases, including c-Met, VEGFR2, Axl, Mer and Flt3, thereby inhibiting their signaling pathways. This inhibits growth, angiogenesis and metastasis of tumor cells that overexpress these kinases. c-Met, VEGFR2, Axl, Mer and Flt3 are overexpressed by many tumor cell types and play key roles in tumor cell proliferation, survival, invasion and metastasis.

CAS Number1394820-77-9
PubChem CID73442844
IUPAC NameN-[3-fluoro-4-[7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl]oxyphenyl]-1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxamide;4-methylbenzenesulfonic acid
Molecular FormulaC38H37FN4O8S
Molecular Weight728.8
Topological Polar Surface Area167
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count9
Heavy Atom Count52
Formal Charge0
Complexity1190
SMILES
CC1=CC=C(C=C1)S(=O)(=O)O.CC1=C(C(=O)N(N1C)C2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OCC(C)(C)O)F
InChI
InChI=1S/C31H29FN4O5.C7H8O3S/c1-19-28(30(38)36(35(19)4)21-8-6-5-7-9-21)29(37)34-20-10-13-27(24(32)16-20)41-26-14-15-33-25-17-22(11-12-23(25)26)40-18-31(2,3)39;1-6-2-4-7(5-3-6)11(8,9)10/h5-17,39H,18H2,1-4H3,(H,34,37);2-5H,1H3,(H,8,9,10)
InChIKey
NAUYISNCVNUUDK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ningetinib Tosylate
CAS: 1394820-77-9
CID: 73442844
Formula: C38H37FN4O8S
MW: 728.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight728.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count9
Exact Mass728.23161349
Monoisotopic Mass728.23161349
Topological Polar Surface Area167 Ų
Heavy Atom Count52
Formal Charge0
Complexity1190
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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