Products for Research Use Only
RegisterLogin

Ningetinib Tosylate

CAT: 0127-BUP10944-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0127-BUP10944-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1394820-77-9
Purity
=98%
Smiles
Cc1ccc(cc1)S(O)(=O)=O.Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCC(C)(C)O)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C

Chemical Information

Ningetinib Tosylate

Ningetinib Tosylate is the tosylate salt form of ningetinib, an orally available inhibitor of the receptor tyrosine kinases c-MET/hepatocyte growth factor receptor (HGFR), vascular endothelial growth factor receptor 2 (VEGFR2 KDR), Axl (UFO), Mer, and Fms-like tyrosine kinase 3 (Flt3; CD135; STK1; FLK2), with antineoplastic activity. Upon administration, ningetinib binds to a variety of kinases, including c-Met, VEGFR2, Axl, Mer and Flt3, thereby inhibiting their signaling pathways. This inhibits growth, angiogenesis and metastasis of tumor cells that overexpress these kinases. c-Met, VEGFR2, Axl, Mer and Flt3 are overexpressed by many tumor cell types and play key roles in tumor cell proliferation, survival, invasion and metastasis.

CAS Number1394820-77-9
PubChem CID73442844
IUPAC NameN-[3-fluoro-4-[7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl]oxyphenyl]-1,5-dimethyl-3-oxo-2-phenylpyrazole-4-carboxamide;4-methylbenzenesulfonic acid
Molecular FormulaC38H37FN4O8S
Molecular Weight728.8
Topological Polar Surface Area167
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count9
Heavy Atom Count52
Formal Charge0
Complexity1190
SMILES
CC1=CC=C(C=C1)S(=O)(=O)O.CC1=C(C(=O)N(N1C)C2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OCC(C)(C)O)F
InChI
InChI=1S/C31H29FN4O5.C7H8O3S/c1-19-28(30(38)36(35(19)4)21-8-6-5-7-9-21)29(37)34-20-10-13-27(24(32)16-20)41-26-14-15-33-25-17-22(11-12-23(25)26)40-18-31(2,3)39;1-6-2-4-7(5-3-6)11(8,9)10/h5-17,39H,18H2,1-4H3,(H,34,37);2-5H,1H3,(H,8,9,10)
InChIKey
NAUYISNCVNUUDK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ningetinib Tosylate
CAS: 1394820-77-9
CID: 73442844
Formula: C38H37FN4O8S
MW: 728.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight728.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count9
Exact Mass728.23161349
Monoisotopic Mass728.23161349
Topological Polar Surface Area167 Ų
Heavy Atom Count52
Formal Charge0
Complexity1190
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
BUP05854-01Ningetinib
BUP03928-01Glycopyrronium tosylate
OR1026293-01Bretylium Tosylate
BISN0216-01Sorafenib tosylate
OR1023798-01Clofilium Tosylate
BUP11370-01TMPyP4 tosylate
BUP09809-01Bretylium tosylate
BUP09196-01Allitinib tosylate
BUP05798-01Clofilium tosylate
BUP05772-01Talazoparib tosylate

Alternative Products

CatalogName
GTR19156180-01Ningetinib Tosylate
A17039-5Ningetinib Tosylate 5mg
A17039-25Ningetinib Tosylate 25mg
A17039-10Ningetinib Tosylate 10mg
A17039-100Ningetinib Tosylate 100mg
A17039-50Ningetinib Tosylate 50mg
A17039-10mM-DNingetinib Tosylate 10mM * 1mL in DMSO
M22115-01Ningetinib

Popular Products