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Ningetinib

CAT: 0013-GTR19157797-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157797-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ningetinib (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.In cell-based functional assays, Ningetinib inhibits VEGF and HGF-stimulated HUVEC proliferation and microvascular angiogenesis in rat aortic rings with IC50 values of 6.3 and 8.6 nM, respectively.In the orthotopic U87MG human glioblastoma xenograft model, Ningetinib prolongs the median survival time and yields a significant increase in life-span value (ILS=32%) at an oral dose of 20 mg/kg/day (dosed 21 days) versus the vehicle-treated group. When single dosed orally (3 mg/kg) to U87MG tumor-bearing nude mice, Ningetinib potently inhibits the phosphorylation of c-Met and its downstream signaling kinases AKT and ERK1/2 for up to 6 hours in tumor tissues.
CAS Number
1394820-69-9
Product Name Alternative
CT-053, CT053PTSA
Purity
>98% (HPLC)
Solubility
DMSO:15 mg/mL (26.95 mM; Need ultrasonic)
Smiles
Cc1c (C (=O) Nc2ccc (Oc3ccnc4cc (OCC (C) (C) O) ccc34) c (F) c2) c (=O) n (-c2ccccc2) n1C
Molecular Formula
C31H29FN4O5
Molecular Weight
556.58
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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