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PF-543 HCl

CAT: 0013-GTR19165826-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19165826-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-543 hydrochloride is a potent and selective sphingosine kinase 1 (SphK1) inhibitor with a K (i) of 3.6 nM. It acts as a competitive antagonist of sphingosine and exhibits over 100-fold selectivity for SphK1 versus SphK2. This tool compound is widely used in vitro and in vivo to investigate the role of SphK1 in cancer, inflammation, and other sphingolipid-mediated pathways.
CAS Number
1706522-79-3
Product Name Alternative
PF 543, PF543, PF-543, PF-543 HCL, PF-543 Hydrochloride, SK1, Sphingosine kinase, Sphingosine Kinase 1 Inhibitor II, sphingosine-competitive, SphK, SphK1, S1PReceptor, S1P, S1P Receptor, Nrf-2, LPLReceptor, LPL Receptor, LPL, Lysophospholipid Receptor, PAH, necrosis, Autophagy, Apoptosis, caspase-3/7
Field of Research
Cell Biology
Purity
>98%
Form
Powder
Solubility
Soluble in DMSO (50 mg/ml) ; or Water (5 mg/mL with warming)
Smiles
Cl.Cc1cc (CS (=O) (=O) c2ccccc2) cc (OCc2ccc (CN3CCC[C@@H]3CO) cc2) c1
Molecular Formula
C27H31NO4S·HCl
Molecular Weight
502.1
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
[ (2R) -1-[[4-[[3- (Benzenesulfonylmethyl) -5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanol hydrochloride

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