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(S) -Sunvozertinib

CAT: 0013-GTR19165626-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19165626-05Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(S) -Sunvozertinib (DZD9008) is an irreversible, selective inhibitor targeting EGFR and HER2 tyrosine kinases. It is a research tool for investigating oncogenic mutations in preclinical models, demonstrating activity in both cellular assays and in vivo studies against EGFR-mutant cancers, including those with exon 20 insertions.
CAS Number
2370013-49-1
Product Name Alternative
Btk, Bruton tyrosine kinase, (S) Sunvozertinib, (S) -DZD9008, (S) Sunvozertinib, (S) -Sunvozertinib, DZD 9008, DZD9008, DZD-9008, breast cancer, Epidermal growth factor receptor, ErbB-1, EGFR, HER2, HER1, Her2, Inhibitor, mutant forms of ErbB, inhibit, lung, N-[5-[[4-[5-Chloro-4-fluoro-2- (2-hydroxypropan-2-yl) anilino]pyrimidin-2-yl]amino]-2-[ (3S) -3- (dimethylamino) pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide, Sunvozertinib
Field of Research
Cardiovascular Research, Signal Transduction
Purity
99.64% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.42 mM) ; DMSO:55 mg/mL (94.17 mM)
Smiles
COc1cc (N2CC[C@@H] (C2) N (C) C) c (NC (=O) C=C) cc1Nc1nccc (Nc2cc (Cl) c (F) cc2C (C) (C) O) n1
Molecular Formula
C29H35ClFN7O3
Molecular Weight
584.08
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(S)-Sunvozertinib
CAS Number2370013-49-1
PubChem CID139377763
IUPAC NameN-[5-[[4-[5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide
Molecular FormulaC29H35ClFN7O3
Molecular Weight584.1
XLogP5
Topological Polar Surface Area115
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count10
Rotatable Bond Count10
Heavy Atom Count41
Formal Charge0
Complexity885
SMILES
CC(C)(C1=CC(=C(C=C1NC2=NC(=NC=C2)NC3=C(C=C(C(=C3)NC(=O)C=C)N4CC[C@@H](C4)N(C)C)OC)Cl)F)O
InChI
InChI=1S/C29H35ClFN7O3/c1-7-27(39)34-22-14-23(25(41-6)15-24(22)38-11-9-17(16-38)37(4)5)35-28-32-10-8-26(36-28)33-21-13-19(30)20(31)12-18(21)29(2,3)40/h7-8,10,12-15,17,40H,1,9,11,16H2,2-6H3,(H,34,39)(H2,32,33,35,36)/t17-/m0/s1
InChIKey
BTMKEDDEMKKSEF-KRWDZBQOSA-N
Chemical Structure
2D Structure
2D structure of (S)-Sunvozertinib
CAS: 2370013-49-1
CID: 139377763
Formula: C29H35ClFN7O3
MW: 584.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight584.1
XLogP35
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count10
Rotatable Bond Count10
Exact Mass583.2473939
Monoisotopic Mass583.2473939
Topological Polar Surface Area115 Ų
Heavy Atom Count41
Formal Charge0
Complexity885
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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