CU-115

CAT: 0013-GTR19164668-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19164668-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

CU-115 is a potent and selective TLR8 antagonist (IC50 = 1.04 μM) that shows minimal activity against TLR7 (>50 μM) . It effectively inhibits R-848-induced TNF-α and IL-1β production in THP-1 cells, making it a valuable tool for studying TLR8-mediated signaling in autoimmune and inflammatory disease research.

CAS Number

2471982-20-2

Product Name Alternative

TLR8, N- (4- (3,5-bis (trifluoromethyl) phenoxy) phenyl) -2-fluoro-6-iodobenzamide, CU115, CU-115, CU 115

Field of Research

Immunology & Inflammation

Purity

99.96% (May vary between batches)

Solubility

DMSO:45 mg/mL (79.06 mM) ;10% DMSO+90% Corn Oil:2 mg/mL (3.51 mM)

Smiles

Fc1cccc (I) c1C (=O) Nc1ccc (Oc2cc (cc (c2) C (F) (F) F) C (F) (F) F) cc1

Molecular Formula

C21H11F7INO2

Molecular Weight

569.21

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide

CAS Number	2471982-20-2
PubChem CID	154734323
IUPAC Name	N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-iodobenzamide
Molecular Formula	C21H11F7INO2
Molecular Weight	569.2
XLogP	6.8
Topological Polar Surface Area	38.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	4
Heavy Atom Count	32
Formal Charge	0
Complexity	615

SMILES

C1=CC(=C(C(=C1)I)C(=O)NC2=CC=C(C=C2)OC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)F

InChI

InChI=1S/C21H11F7INO2/c22-16-2-1-3-17(29)18(16)19(31)30-13-4-6-14(7-5-13)32-15-9-11(20(23,24)25)8-12(10-15)21(26,27)28/h1-10H,(H,30,31)

InChIKey

QYSLCRYVUJORPX-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2471982-20-2

CID: 154734323

Formula: C21H11F7INO2

MW: 569.2

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	569.2
XLogP3	6.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	4
Exact Mass	568.97227
Monoisotopic Mass	568.97227
Topological Polar Surface Area	38.3 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	615
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
T9645-01	CU-115
sc-221270	(−) -AS 115
sc-205216A	(+) -AS 115
S8060-11B	Superoxide Dismutase, Cu (SOD Cu)
555051	ZZW-115
205829	CC-115
HY-121493-01	TM2-115
T70129-01	ST-115
467444-01	TG100-115
456188-01	MG-115

CU-115

Chemical Information

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