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R1530

CAT: 0013-GTR19164451-04Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19164451-04Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
R1530 is a small molecule multikinase inhibitor exhibiting both antitumor and antiangiogenic properties. It is utilized in cancer research, with studies demonstrating its activity in inhibiting tumor growth and angiogenesis in both cellular and animal models.
CAS Number
882531-87-5
Product Name Alternative
R1530, R-1530, R 1530, VEGFR1, VEGFR, VEGFR2, Vascular endothelial growth factor receptor, VEGFR3, FLT3, FGFR2, Fibroblast growth factor receptor, FGFR1, FGFR, Inhibitor, inhibit, PDGFR, mitosis, mitotic, antitumor, antiproliferative, Apoptosis, angiogenesis
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
97.96% (May vary between batches)
Solubility
DMSO:5 mg/mL (14.01 mM)
Smiles
COc1cc2N=C3NNC (C) =C3N=C (c3ccccc3Cl) c2cc1F
Molecular Formula
C18H14ClFN4O
Molecular Weight
356.78
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.

Chemical Information

R-1530

Receptor Tyrosine Kinase Inhibitor R1530 is a pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. Mitosis-angiogenesis inhibitor (MAI) R1530 inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR)-1, -2, -3, platelet-derived growth factor receptor (PDGFR) beta, FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2. In addition, this agents exhibits anti-proliferative activity by initiating mitotic arrest and inducing apoptosis.

CAS Number882531-87-5
PubChem CID135398512
IUPAC Name5-(2-chlorophenyl)-7-fluoro-8-methoxy-3-methyl-2,10-dihydropyrazolo[3,4-b][1,4]benzodiazepine
Molecular FormulaC18H14ClFN4O
Molecular Weight356.8
XLogP4.4
Topological Polar Surface Area62.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count25
Formal Charge0
Complexity521
SMILES
CC1=C2C(=NN1)NC3=CC(=C(C=C3C(=N2)C4=CC=CC=C4Cl)F)OC
InChI
InChI=1S/C18H14ClFN4O/c1-9-16-18(24-23-9)21-14-8-15(25-2)13(20)7-11(14)17(22-16)10-5-3-4-6-12(10)19/h3-8H,1-2H3,(H2,21,23,24)
InChIKey
UOVCGJXDGOGOCZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of R-1530
CAS: 882531-87-5
CID: 135398512
Formula: C18H14ClFN4O
MW: 356.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight356.8
XLogP34.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass356.0840169
Monoisotopic Mass356.0840169
Topological Polar Surface Area62.3 Ų
Heavy Atom Count25
Formal Charge0
Complexity521
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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