Products for Research Use Only
RegisterLogin

R1530

CAT: 0804-HY-13737-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-13737-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
R1530 is a highly potent, orally active, dual-acting mitosis/angiogenesis inhibitor, with anti-tumor and anti-angiogenic activities. R1530 is a multikinase inhibitor which binds to 31 kinases with Kd values of IC50 of 10 nM and 28 nM, respectively. R1530 triggers apoptosis (mitotic catastrophe) or senescence[1][2].
CAS Number
882531-87-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; FGFR; Mitosis; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/R1530.html
Concentration
10mM
Purity
99.06
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(NN1)=C2C1=NC3=CC(OC)=C(F)C=C3C(C4=CC=CC=C4Cl)=N2
Molecular Formula
C18H14ClFN4O
Molecular Weight
356.78
Precautions
H302, H315, H319, H335
References & Citations
[1]Jin-Jun Liu, et al. Discovery of a Highly Potent, Orally Active Mitosis/Angiogenesis Inhibitor R1530 for the Treatment of Solid Tumors. ACS Med Chem Lett. 2013 Feb 14; 4 (2) : 259–263.|[2]Christian Tovar, et al. Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy. Cell Cycle. 2010 Aug 15;9 (16) :3364-75.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1

Alternative Products

CatalogName
A13111-10R1530 10mg
A3746-10R1530
A13111-25R1530 25mg
A13111-1R1530 1mg
A13111-100R1530 100mg
A13111-50R1530 50mg
A13111-5R1530 5mg
A13111-2R1530 2mg
SF5404-5mgR1530 (VEGFR inhibitor)

Popular Products