Vanillin

Vanillin is mainly used as a flavouring agent, primarily in foods and beverages such as chocolate and dairy products, but also to mask unpleasant tastes in medicines or livestock fodder. It is also an intermediate in the manufacture of certain pharmaceuticals and agrochemicals. (In Vitro) :Vanillin recovers UVA-induced reduction of proliferation in a dose dependent manner. Vanillin has no apoptotic effects at the tested concentrations. In addition, the reduced expression levels of OCT4, NANOG, and SOX2 caused by UVA irradiation are all increased by Vanillin treatment, suggesting that Vanillin attenuates the effects of UVA irradiation on hAMSCs. Based on a luciferase reporter assay, Vanillin increases the reduced activity of HRE-luciferase reporter caused by UVA irradiation. In addition, treatment with Vanillin attenuates the reduced expression of HIF-1α caused by UVA irradiation. The results reveal that treatment of hAMSCs with Vanillin results in significant decrease in the production of PGE2 and cAMP when compare to UVA-irradiated controls. (In Vivo) :Following antidepressant treatment for 4 weeks, immobility time in the stress+Vanillin and stress+fluoxetine groups is significantly decreased [F (4,42) =34.73, P<0.01; F (4,42) =13.55, P<0.01, respectively]. Treatment with Vanillin or fluoxetine remarkably alleviates the decrease in sucrose consumption in CUMS model animals [F (4,42) =12.32, P<0.01; F (4,42) =5.65, P<0.01, respectively]. In CUMS model rats, 5-HT level in the stress+Vanillin and stress+fluoxetine groups is significantly increased when compare with the stress group [F (4,42) =4.846, P=0.030; F (4,42) =4.846, P=0.036, respectively], whereas noradrenaline (NE) in the two groups is elevated but not significantly [F (4,42) =6.977, n.s.]. Dopamine (DA) is also significantly increased in the stress+Vanillin group compare with the stress group [F (4.42) =6.174, P=0.041].

121-33-5

Vanillin | NSC 15351 | NSC-15351 | NSC15351

>98% (HPLC)

Ethanol: 30 mg/mL (197.17 mM) ; DMSO: 30 mg/mL (197.17 mM)

O=CC1=CC=C (O) C (OC) =C1

C8H8O3

152.15

Storage temperature: -20°C. Stability: ≥ 2 years

For research use only.