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Sivelestat

CAT: 0013-GTR19163940-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19163940-01Size:1 g
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Description
A potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM; also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse, do not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G (>10 uM) ; attenuates LPS-induced acute lung inflammation in the hamster.Other Indication Approved (In Vitro) :Sivelestat (ONO-5046) does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM.Sivelestat (ONO-5046) exhibits IC50 values of 44 nM, 36 nM, 19 nM, 37 nM and 49 nM for human, rabbit, rat, hamster and mouse neutrophil elastase, respectively. (In Vivo) :Sivelestat (ONO-5046, 0.021-2.1 mg/kg, intratracheally) suppresses lung hemorrhage in hamster (ID50 = 82 pg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which are induced by human neutrophil elastase.Sivelestat (10 mg/kg, infusion via the tail vein) ameliorates lung injury after hemorrhagic shock in rats.Sivelestat (15, 60 mg/kg, ip) prevents ischemia–reperfusion injury in the rat bladder.
CAS Number
127373-66-4
Product Name Alternative
EI-546 | LY-544349 | ONO-5046
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC (C) (C) C (=O) OC1=CC=C (C=C1) S (=O) (=O) NC2=CC=CC=C2C (=O) NCC (=O) O
Molecular Formula
C20H22N2O7S
Molecular Weight
434.4629
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Propanoic acid, 2,2-dimethyl-, 4-[[[2-[[ (carboxymethyl) amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester

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