Sivelestat (Standard)

CAT: 0804-HY-17443R-01Size: 5 mgDry Ice: NoHazardous: No

CAT#:0804-HY-17443R-01Size:5 mg

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Description

Sivelestat (Standard) is the analytical standard of Sivelestat. This product is intended for research and analytical applications. Sivelestat (EI546) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19[1][2][3][4].

CAS Number

[127373-66-4]

UNSPSC

12352100

Target

Elastase; Reference Standards; SARS-CoV

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Smiles

CC(C)(C)C(OC1=CC=C(S(=O)(NC2=CC=CC=C2C(NCC(O)=O)=O)=O)C=C1)=O

Molecular Formula

C20H22N2O7S

Molecular Weight

434.46

References & Citations

[1]Kawabata K, et al. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun. 1991 Jun 14;177 (2) :814-20.|[2]Yuichiro Toda, et al. A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats. Int J Mol Med. 2007 Feb;19 (2) :237-43.|[3]Tomoharu Kono, et al. Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder. Mol Cell Biochem. 2008 Apr;311 (1-2) :87-92.|[4]Adeleh Sahebnasagh, et al. Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19. J Clin Pharm Ther. 2020 Aug 28.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

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T6986-01	Sivelestat
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A14184-5	Sivelestat 5mg
A14184-10	Sivelestat 10mg
A14184-200	Sivelestat 200mg
A14184-25	Sivelestat 25mg
A14184-50	Sivelestat 50mg
A14184-100	Sivelestat 100mg
A14184-500	Sivelestat 500mg

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