Blonanserin

CAT: 0013-GTR19163842-02Size: 1 gDry Ice: NoHazardous: No

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Description

Blonanserin is a novel atypical antipsychotic agent with potent dopamine D2 and serotonin 5-HT2 receptors antagonist properties. (In Vitro) :Blonanserin exerts some blockade of α1-adrenergic receptors (Ki=26.7 nM) and also shows significant affinity for the D3 receptor (Ki=0.494 nM) . Blonanserin possesses low affinity for the sigma receptor (IC50=286 nM), but lacks significant affinity for numerous other sites including the 5-HT1A, 5-HT3, D1, α2-adrenergic, β-adrenergic, H1, and mACh receptors and the monoamine transporters. (In Vivo) :Blonanserin (oral gavage; 1 mg/kg; 14 days) significantly ameliorates the social deficit observed in PCP-administered mice and inhibits the decrease in the levels of Ser897-phosphorylation, but preatment with blonanserin does not affect the social behaviors in saline-administered mice.

CAS Number

132810-10-7

Product Name Alternative

AD5423 | Lonasen

Field of Research

Pharmacology & Drug Discovery

Purity

>98% (HPLC)

Solubility

Ethanol: <1 mg/mL (<1 mM) ; Water: <1 mg/mL (<1 mM) ; DMSO: <1 mg/mL (<1 mM)

Smiles

CCN1CCN (CC1) C1=NC2=C (CCCCCC2) C (=C1) C1=CC=C (F) C=C1

Molecular Formula

C23H30FN3

Molecular Weight

367.5

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Chemical Information

Blonanserin

Blonanserin is an organic molecular entity.

CAS Number	132810-10-7
PubChem CID	125564
IUPAC Name	2-(4-ethylpiperazin-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
Molecular Formula	C23H30FN3
Molecular Weight	367.5
XLogP	5.5
Topological Polar Surface Area	19.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Heavy Atom Count	27
Formal Charge	0
Complexity	443

SMILES

CCN1CCN(CC1)C2=NC3=C(CCCCCC3)C(=C2)C4=CC=C(C=C4)F

InChI

InChI=1S/C23H30FN3/c1-2-26-13-15-27(16-14-26)23-17-21(18-9-11-19(24)12-10-18)20-7-5-3-4-6-8-22(20)25-23/h9-12,17H,2-8,13-16H2,1H3

InChIKey

XVGOZDAJGBALKS-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 132810-10-7

CID: 125564

Formula: C23H30FN3

MW: 367.5

Interactive 3D Structure

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Computed Properties

Property	Value
Molecular Weight	367.5
XLogP3	5.5
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	367.24237613
Monoisotopic Mass	367.24237613
Topological Polar Surface Area	19.4 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	443
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
MBS3601308-01	Blonanserin
HFA81184-01	Blonanserin C
MBS5766962	Blonanserin HCl
MBS5766193	Blonanserin D8

Blonanserin

Chemical Information

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