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Atorvastatin

CAT: 0013-GTR19217862-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19217862-01Size:100 mg
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Description
A competitive inhibitor of HMG-CoA reductase that acts as a lipid-lowering agent for prevention of events associated with cardiovascular disease.Dyslipidemia Approved (In Vitro) :Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation. (In Vivo) :Atorvastatin (20-30 mg/kg; oral gavage; once a day; for 28 days; ApoE / mice) treatment significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin treatment.
CAS Number
134523-00-5
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC (C) C1=C (C (=C (N1CCC (CC (CC (=O) O) O) O) C2=CC=C (C=C2) F) C3=CC=CC=C3) C (=O) NC4=CC=CC=C4
Molecular Formula
C33H35FN2O5
Molecular Weight
558.6398
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Pyrrole-1-heptanoic acid, 2- (4-fluorophenyl) -β, δ-dihydroxy-5- (1-methylethyl) -3-phenyl-4-[ (phenylamino) carbonyl]-, (βR, δR) -

Alternative Products

CatalogName
FA156586-01Atorvastatin

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