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TP-3654

CAT: 0013-GTR19163745-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163745-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent, selective, orally active second-generation PIM inhibitor with Ki of 5, 42 and 239 nM for Pim1, 2 and 3, respectively; exhibits submicromolar activity in UM-UC-3 bladder cancer cell line; displays favorabl hERG and CYP450 inhibition profiles compared with SGI-1776, reduces tumor growth in vivo xenografts. (In Vitro) :TP-3654 demonstrates potent PIM-1 specific cellular activity in the PIM-1/BAD overexpression system with an average EC50 of 67 nM. TP-3654 treatment reduces levels of phospho-BAD in vitro using the bladder cancer cell line UM-UC-3. TP-3654 reduces colony growth of T24 and UM-UC3 cells, confirming the PIM-1–dependent growth for both cell lines. (In Vivo) :Oral dosing of 200 mg/kg TP-3654 significantly reduces both UM-UC-3 and PC-3 tumor growth measured by volume (caliper) and by final tumor weight, with no significant changes in body weight or gross adverse toxicity.
CAS Number
1361951-15-6
Product Name Alternative
TP3654 | TP 3654
Purity
>98% (HPLC)
Solubility
DMSO: 10 mM
Smiles
OC (C) (C) [C@H]1CC[C@H] (NC2=NN3C (C=C2) =NC=C3C4=CC=CC (C (F) (F) F) =C4) CC1
Molecular Formula
C22H25F3N4O
Molecular Weight
418.4553096
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Cyclohexanemethanol, α, α-dimethyl-4-[[3-[3- (trifluoromethyl) phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]-, trans-

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Alternative Products

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BA6395-100TP-3654
A20584-100TP-3654 100mg
A20584-50TP-3654 50mg
A20584-25TP-3654 25mg
HY-101126RTP-3654 (Standard)
A20584-5TP-3654 5mg
A20584-10TP-3654 10mg
A20584-10mM-DTP-3654 10mM * 1mL in DMSO

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