Rapastinel

CAT: 0013-GTR19164423-01Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19164423-01Size:100 mg

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Description

A tetrapeptide (TPPT-amide) that acts as a NMDA receptor glycine site partial agonist; readily crosses the blood-brain barrier and modulates the NMDA receptor, shows potent cognitive-enhancing properties in a valid in vivo model of learning.Depression Phase 3 Clinical.

CAS Number

117928-94-6

Product Name Alternative

GLYX-13 | Thr-Pro-Pro-Thr-NH2

Purity

>98% (HPLC)

Solubility

DMSO: ≥ 32 mg/mL

Smiles

C[C@@H] (O) [C@@H] (C (N) =O) NC ([C@H]1N (C ([C@H]2N (C ([C@H] ([C@H] (O) C) N) =O) CCC2) =O) CCC1) =O

Molecular Formula

C18H31N5O6

Molecular Weight

413.4686

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

L-Threoninamide, L-threonyl-L-prolyl-L-prolyl-

Chemical Information

Rapastinel

Rapastinel has been used in trials studying the treatment of Depressive Disorder, Major and Obsessive-Compulsive Disorder (OCD).

CAS Number	117928-94-6
PubChem CID	14539800
IUPAC Name	(2S)-1-[(2S)-1-[(2S,3R)-2-amino-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]pyrrolidine-2-carboxamide
Molecular Formula	C18H31N5O6
Molecular Weight	413.5
XLogP	-2.8
Topological Polar Surface Area	179
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Heavy Atom Count	29
Formal Charge	0
Complexity	659

SMILES

C[C@H]([C@@H](C(=O)N1CCC[C@H]1C(=O)N2CCC[C@H]2C(=O)N[C@@H]([C@@H](C)O)C(=O)N)N)O

InChI

InChI=1S/C18H31N5O6/c1-9(24)13(19)18(29)23-8-4-6-12(23)17(28)22-7-3-5-11(22)16(27)21-14(10(2)25)15(20)26/h9-14,24-25H,3-8,19H2,1-2H3,(H2,20,26)(H,21,27)/t9-,10-,11+,12+,13+,14+/m1/s1

InChIKey

GIBQQARAXHVEGD-BSOLPCOYSA-N

Chemical Structure

2D Structure

CAS: 117928-94-6

CID: 14539800

Formula: C18H31N5O6

MW: 413.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	413.5
XLogP3	-2.8
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	413.22743373
Monoisotopic Mass	413.22743373
Topological Polar Surface Area	179 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	659
Isotope Atom Count	0
Defined Atom Stereocenter Count	6
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
326679	Rapastinel
MBS3610384-01	Rapastinel Trifluoroacetate
MBS3616586-01	Rapastinel acetate
HY-16728A	Rapastinel (acetate)
HY-16728B-01	Rapastinel (Trifluoroacetate)
C12307-25mg	Rapastinel (GLYX-13)
MBS384777-01	GLYX-13 (Rapastinel)
A13576-50	GLYX-13 (Rapastinel) 50mg
A13576-25	GLYX-13 (Rapastinel) 25mg
A13576-1	GLYX-13 (Rapastinel) 1mg

Rapastinel

Chemical Information

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