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EZM 2302

CAT: 0013-GTR19163913-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163913-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EZM 2302 (EZM2302, GSK 3359088) is a potent, selective, orally available arginine methyltransferase CARM1 inhibitor with IC50 of 6 nM, with broad selectivity against other HMTases; demonstrates in vitro anti-proliferative activity consistent with specific methyl mark inhibition with IC50 of <100 nM in 9/15 multiple myeloma cell lines, decreases methylation of PABP1 (IC50 =38 nM) and SmB (IC50=18 nM) ; displays dose-dependent inhibition of CARM1 substrate methylation in vivo, and induces growth inhibition of human multiple myeloma tumor xenografts in mice.
CAS Number
1628830-21-6
Product Name Alternative
GSK 3359088 | GSK3359088 | EZM2302
Purity
>98% (HPLC)
Solubility
100 mM in DMSO
Smiles
O=C (N (CC1) CCC21CN (C3=NC (C4=CC (OC[C@H] (O) CNC) =CC=C4Cl) =NC (C5=C (C) ON=C5C) =C3C) C2) OC
Molecular Formula
C29H37ClN6O5
Molecular Weight
585.102
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Methyl (R) -2- (2- (2-chloro-5- (2-hydroxy-3- (methylamino) propoxy) phenyl) -6- (3,5-dimethylisoxazol-4-yl) -5-methylpyrimidin-4-yl) -2,7-diazaspiro[3.5]nonane-7-carboxylate

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MBS3843939-01EZM 2302
HY-172365P7–2302
T70344-01BJ-2302
A19484-50EZM 2302 50mg
A19484-10EZM 2302 10mg
A19484-100EZM 2302 100mg
A19484-5EZM 2302 5mg
A19484-1EZM 2302 1mg
C12132-25mgEZM 2302 (GSK3359088)
A19484-25EZM 2302 25mg

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