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YM-90709

CAT: 0013-GTR19163780-02Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163780-02Size:500 mg
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Description
A potent IL-5 receptor antagonist that inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells with IC50 of 1.0 and 0.57 uM, respectively; inhibits IL-5-prolonged eosinophil survival with IC50 of 0.45 uM and does not affect the GM-CSF-prolonged eosinophil survival; inhibits antigen-induced infiltration of eosinophils and lymphocytes into the bronchoalveolar lavage fluid (BALF) in BN rats (EC50=0.32 mg/kg and 0.12 mg/kg, respectively) .
CAS Number
163769-88-8
Product Name Alternative
YM 90709 | YM90709
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC (CC1=CC (OC) =C (OC) C=C12) (C) N3C2=CC4=NC5=CC=CC=C5N=C43
Molecular Formula
C22H21N3O2
Molecular Weight
359.4211
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benz[7,8]indolizino[2,3-b]quinoxaline, 5,6-dihydro-2,3-dimethoxy-6,6-dimethyl-

Chemical Information

YM 90709

LSM-2128 is a quinoxaline derivative.

CAS Number163769-88-8
PubChem CID1103147
IUPAC Name16,17-dimethoxy-21,21-dimethyl-1,3,10-triazapentacyclo[11.8.0.02,11.04,9.014,19]henicosa-2,4,6,8,10,12,14,16,18-nonaene
Molecular FormulaC22H21N3O2
Molecular Weight359.4
XLogP3.6
Topological Polar Surface Area49.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count27
Formal Charge0
Complexity556
SMILES
CC1(CC2=CC(=C(C=C2C3=CC4=NC5=CC=CC=C5N=C4N31)OC)OC)C
InChI
InChI=1S/C22H21N3O2/c1-22(2)12-13-9-19(26-3)20(27-4)10-14(13)18-11-17-21(25(18)22)24-16-8-6-5-7-15(16)23-17/h5-11H,12H2,1-4H3
InChIKey
HIXSPVQXXDULHS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of YM 90709
CAS: 163769-88-8
CID: 1103147
Formula: C22H21N3O2
MW: 359.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight359.4
XLogP33.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass359.16337692
Monoisotopic Mass359.16337692
Topological Polar Surface Area49.2 Ų
Heavy Atom Count27
Formal Charge0
Complexity556
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
B6825-5YM 90709
HY-19969-01YM-90709
A15999-5YM-90709 5mg
A15999-2YM-90709 2mg
A15999-100YM-90709 100mg
A15999-25YM-90709 25mg
A15999-1YM-90709 1mg
A15999-50YM-90709 50mg
A15999-10YM-90709 10mg

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