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DBET1

CAT: 0013-GTR19163456-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19163456-01Size:1 g
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Description
DBET1 is a proteolysis-targeting chimera (PROTAC) molecule that appendes a competitive antagonist of BET bromodomain (JQ1) to a phthalimide moiety to hijack the cereblon E3 ubiquitin ligase complex; induces highly selective cereblon-dependent BET protein degradation in vitro (EC50=430 nM) and in vivo and delayed leukemia progression in mice.
CAS Number
1799711-21-9
Product Name Alternative
DBET 1
Purity
>98% (HPLC)
Solubility
DMSO: 50 mg/mL; Water: Insoluble; Ethanol: 5 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
CC (N (C1C2=NN=C (C) N2C3=C (C (C) =C (C) S3) C (C4=CC=C (Cl) C=C4) =N1) CCCCNC (COC5=CC=CC (C (N6C (CC7) C (NC7=O) =O) =O) =C5C6=O) =O) =O
Molecular Formula
C38H37ClN8O7S
Molecular Weight
785.273
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(6S) -4- (4-chlorophenyl) -N-[4-[[2-[[2- (2,6-dioxo-3-piperidinyl) -2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide

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ENZ-CHM260-0025DBET1
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A16858-50DBET1 50mg
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A16858-25DBET1 25mg
A16858-5DBET1 5mg
A16858-2DBET1 2mg

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