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SB-225002

CAT: 0013-GTR19163428-08Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163428-08Size:500 mg
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Description
A potent, selective non-peptide CXCR2 antagonist with IC50 of 22 nM; displays >150-fold selectivity over CXCR1; potently inhibits human and rabbit neutrophil chemotaxis induced by both IL-8 and GROalpha in vitro; selectively blocks IL-8-induced neutrophil margination in rabbits.
CAS Number
182498-32-4
Product Name Alternative
SB225002
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (NC1=CC=C ([N+] ([O-]) =O) C=C1O) NC2=CC=CC=C2Br
Molecular Formula
C13H10BrN3O4
Molecular Weight
352.1402
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Urea, N- (2-bromophenyl) -N'- (2-hydroxy-4-nitrophenyl) -

Chemical Information

Sb 225002

SB225002 is a member of the class of phenylureas that is urea in which one of the amino groups is substituted by a (2-bromophenyl)amino group while the other is substituted by a (2-hydroxy-4-nitrophenyl)amino group. It is a potent CXCR2 chemokine receptor antagonist (IC50 = 22 nM). It has a role as an antinociceptive agent, a CXCR2 antagonist, an antineoplastic agent, an anti-inflammatory agent and an apoptosis inducer. It is a member of phenylureas, a nitrophenol and a member of bromobenzenes.

CAS Number182498-32-4
PubChem CID3854666
IUPAC Name1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
Molecular FormulaC13H10BrN3O4
Molecular Weight352.14
XLogP2.6
Topological Polar Surface Area107
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity390
SMILES
C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br
InChI
InChI=1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)
InChIKey
MQBZVUNNWUIPMK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Sb 225002
CAS: 182498-32-4
CID: 3854666
Formula: C13H10BrN3O4
MW: 352.14
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight352.14
XLogP32.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass350.98547
Monoisotopic Mass350.98547
Topological Polar Surface Area107 Ų
Heavy Atom Count21
Formal Charge0
Complexity390
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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