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AMG-333

CAT: 0013-GTR19163277-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163277-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMG-333 (AMG333, AMG 333) is a novel potent, highly selective TRPM8 antagonist with IC50 of 13 nM and 20 nM for hTRPM8 and rTRPM8, respectively; displays high selectivity over other TRP channels (IC50>20 uM, TRPV1/V3/V4/A1) ; exhibits statistically significant and dose-dependent prevention of icilin-induced rat WDS, at 0.6, 1 and 3 mg/kg, inhibits cold-induced increase in blood pressure in the rat CPT in a dose-dependent manner with 1 and 3 mg/kg producing significant inhibition with an ED90 of 1.1 mg/kg, also fully blocks the cold pressor response at 3 mg/kg.Migraine Phase 1 Clinical.
CAS Number
1416799-28-4
Product Name Alternative
AMG333 | AMG 333
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 125 mg/mL 275.74 mM
Smiles
O=C (O) C1=CN=C (C (N[C@@H] (C2=CC=C (OC (F) (F) F) C (F) =C2) C3=NC=CC=C3F) =O) C=C1
Molecular Formula
C20H12F5N3O4
Molecular Weight
453.325
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(S) -6- (((3-fluoro-4- (trifluoromethoxy) phenyl) (3-fluoropyridin-2-yl) methyl) carbamoyl) nicotinic acid

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Alternative Products

CatalogName
6874/50AMG 333
MBS3601738-01AMG-333
A17182-25AMG-333 25mg
A17182-10AMG-333 10mg
A17182-1AMG-333 1mg
A17182-100AMG-333 100mg
A17182-50AMG-333 50mg
A17182-5AMG-333 5mg
A17182-2AMG-333 2mg
A17182-10mM-DAMG-333 10mM * 1mL in DMSO

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