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K02288

CAT: 0013-GTR19163233-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163233-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
K02288 is a potent, selective inhibitor of BMP signaling with IC50 of 1.8/1.1/34.4/6.3 nM for ALK/1/2/3/6, displays 300-fold selectivity for ALK2 over the TGF-β receptor ALK5 and ALK4; also wekaly inhibits type II BMP receptor ActRIIA (IC50=220 nM) ; specifically inhibits the BMP-induced Smad pathway without affecting TGF-β signaling and induces dorsalization of zebrafish embryos; inhibits BMP9-induced phosphorylation of SMAD1/5/8 in HUVECs to reduce both the SMAD and the Notch-dependent transcriptional responses, inhibits functional angiogenesis.
CAS Number
1431985-92-0
Product Name Alternative
K 02288 | K-02288
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 58.6 mg/mL
Smiles
OC1=CC=CC (C2=CC (C3=CC (OC) =C (OC) C (OC) =C3) =C (N) N=C2) =C1
Molecular Formula
C20H20N2O4
Molecular Weight
352.3838
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Phenol, 3-[6-amino-5- (3,4,5-trimethoxyphenyl) -3-pyridinyl]-

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C12632-10mM/1mLK02288

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