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K02288

CAT: 0013-GTR19163233-02Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163233-02Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
K02288 is a potent, selective inhibitor of BMP signaling with IC50 of 1.8/1.1/34.4/6.3 nM for ALK/1/2/3/6, displays 300-fold selectivity for ALK2 over the TGF-β receptor ALK5 and ALK4; also wekaly inhibits type II BMP receptor ActRIIA (IC50=220 nM) ; specifically inhibits the BMP-induced Smad pathway without affecting TGF-β signaling and induces dorsalization of zebrafish embryos; inhibits BMP9-induced phosphorylation of SMAD1/5/8 in HUVECs to reduce both the SMAD and the Notch-dependent transcriptional responses, inhibits functional angiogenesis.
CAS Number
1431985-92-0
Product Name Alternative
K 02288 | K-02288
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 58.6 mg/mL
Smiles
OC1=CC=CC (C2=CC (C3=CC (OC) =C (OC) C (OC) =C3) =C (N) N=C2) =C1
Molecular Formula
C20H20N2O4
Molecular Weight
352.3838
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Phenol, 3-[6-amino-5- (3,4,5-trimethoxyphenyl) -3-pyridinyl]-

Chemical Information

K02288

K02288 is potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors.

CAS Number1431985-92-0
PubChem CID46173038
IUPAC Name3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol
Molecular FormulaC20H20N2O4
Molecular Weight352.4
XLogP3.3
Topological Polar Surface Area86.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count26
Formal Charge0
Complexity424
SMILES
COC1=CC(=CC(=C1OC)OC)C2=C(N=CC(=C2)C3=CC(=CC=C3)O)N
InChI
InChI=1S/C20H20N2O4/c1-24-17-9-13(10-18(25-2)19(17)26-3)16-8-14(11-22-20(16)21)12-5-4-6-15(23)7-12/h4-11,23H,1-3H3,(H2,21,22)
InChIKey
CJLMANFTWLNAKC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of K02288
CAS: 1431985-92-0
CID: 46173038
Formula: C20H20N2O4
MW: 352.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight352.4
XLogP33.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass352.14230712
Monoisotopic Mass352.14230712
Topological Polar Surface Area86.8 Ų
Heavy Atom Count26
Formal Charge0
Complexity424
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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