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SAR-20347

CAT: 0013-GTR19163187-02Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163187-02Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SAR-20347 (SAR20347) is a potent, selective inhibitor of JAK1 and Tyk2 with IC50 of 59 and 13 nM in TR-FRET assays, shows selectivity against JAK2 and JAK3 (IC50>800 nM) ; potently inhibits IL-12-mediated STAT4 phosphorylation with IC50 of 126 nM, inhibits JAK1-mediated IL-6 pSTAT3 signaling with IC50 of 345 nM in TF-1 and 407 nM in CD4+ cells, poorly inhibits JAK2 mediated STAT5 phosphorylation with IC50 of >1 uM; ameliorates imiquimod-induced psoriasis-like dermatitis in vivo.
CAS Number
1450881-55-6
Product Name Alternative
SAR20347
Purity
>98% (HPLC)
Solubility
DMSO: 100 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (C1=C (NC2=CC=C (C (N3CCOCC3) =O) C=C2) OC (C4=C (F) C=CC=C4Cl) =N1) N
Molecular Formula
C21H18ClFN4O4
Molecular Weight
444.847
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (2-chloro-6-fluorophenyl) -5- ((4- (morpholine-4-carbonyl) phenyl) amino) oxazole-4-carboxamide

Chemical Information

2-(2-Chloro-6-fluorophenyl)-5-((4-(morpholine-4-carbonyl)phenyl)amino)oxazole-4-carboxamide
CAS Number1450881-55-6
PubChem CID71727668
IUPAC Name2-(2-chloro-6-fluorophenyl)-5-[4-(morpholine-4-carbonyl)anilino]-1,3-oxazole-4-carboxamide
Molecular FormulaC21H18ClFN4O4
Molecular Weight444.8
XLogP3.5
Topological Polar Surface Area111
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count31
Formal Charge0
Complexity645
SMILES
C1COCCN1C(=O)C2=CC=C(C=C2)NC3=C(N=C(O3)C4=C(C=CC=C4Cl)F)C(=O)N
InChI
InChI=1S/C21H18ClFN4O4/c22-14-2-1-3-15(23)16(14)19-26-17(18(24)28)20(31-19)25-13-6-4-12(5-7-13)21(29)27-8-10-30-11-9-27/h1-7,25H,8-11H2,(H2,24,28)
InChIKey
HEDPDFHTQKEORT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(2-Chloro-6-fluorophenyl)-5-((4-(morpholine-4-carbonyl)phenyl)amino)oxazole-4-carboxamide
CAS: 1450881-55-6
CID: 71727668
Formula: C21H18ClFN4O4
MW: 444.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight444.8
XLogP33.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass444.1000609
Monoisotopic Mass444.1000609
Topological Polar Surface Area111 Ų
Heavy Atom Count31
Formal Charge0
Complexity645
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
HY-100895-01SAR-20347
HY-100895RSAR-20347 (Standard)
A20380-100SAR-20347 100mg
A20380-50SAR-20347 50mg

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