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Serotonin hydrochloride

CAT: 0013-GTR19163056-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163056-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Serotonin hydrochloride is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist. (In Vitro) :Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (Ki= 44 μM) . Results show that addition of 100 μM of Serotonin hydrochloride decreases the reaction velocity of COMT. (In Vivo) :Serotonin hydrochloride produces robust hypersensitivity compare to saline-treated controls (p<0.001) . A significant increase in colonic 5-HT content is observed in IL-13-/- mice receiving Serotonin hydrochloride compare to IL-13-/- receiving vehicle following induction of DSS colitis.
CAS Number
153-98-0
Product Name Alternative
5-HT | 5-Hydroxytryptamine
Field of Research
Neuroscience
Purity
>98% (HPLC)
Solubility
Ethanol: 2 mg/mL (9.4 mM) ; Water: 43 mg/mL (202.18 mM) ; DMSO: 43 mg/mL (202.18 mM)
Smiles
Cl.NCCC1=CNC2=C1C=C (O) C=C2
Molecular Formula
C10H12N2O·HCl
Molecular Weight
212.68
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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